Corace Tablet - Uses, Side Effects, Precautions and FAQs
Uses
How To Use
- Take this medicine by mouth with a glass of water.
- Take this medicine with or without food.
- Swallow it as a whole, do not crush or chew the medicine.
- Take it at the same time to help you remember.
- Or use it exactly as instructed by your doctor.
Expert Advice
- Follow the diet instructed by your doctor
- Drink enough fluids to prevent dehydration.
- Do not share this medicine with anyone.
- Do not use more than the recommended amount.
- Do not skip or alter the dose.
- Inform your doctor immediately if you experience serious side effects.
Primary Uses
HypertensionShort Description
Lisinopril is an oral antihypertensive and heart failure medicine that belongs to the class of Angiotensin-converting enzyme inhibitors (ACE inhibitors). It works by dilating the blood vessels to improve blood flow; lowering blood pressure and reducing stress on the heart. Hypertension is a common disease in which the blood pressure in arteries is so high that your heart has to work more than normal. Continuous high blood pressure will eventually cause serious health problems like heart attack, stroke, or kidney failure. Lisinopril improves the chances of survival after a heart attack.
Side Effects
Common: Dizziness, headache, orthostatic effects (including hypotension), cough, diarrhea, nausea, vomiting.Uncommon: Mood alterations, paraesthesia, vertigo, taste disturbance, sleep disturbances, myocardial infarction or cerebrovascular accident, possibly secondary to excessive hypotension in high risk patients, palpitations, tachycardia. Raynaud's phenomenon, rhinitis, abdominal pain and indigestion, rash, pruritus, impotence, fatigue, asthenia, increase in blood urea, increase in serum creatinine, increasein liver enzymes, hyperkalaemia.Rare: Decrease in hemoglobin, decrease in hematocrit, mental confusion, dry mouth, hypersensitivity/angioneurotic edema: angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx, urticaria, alopecia, psoriasis, uraemia, acute renal failure.Very rare: Bone marrow depression, anaemia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, haemolytic anaemia, lymphadenopathy, autoimmune disease, hypoglycemia, bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia, pancreatitis, intestinal angioedema, hepatitis - either hepatocellular or cholestatic, jaundice and hepatic failure, diaphoresis, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, oliguria/anuria, gynaecomastia, increase in serum bilirubin, hyponatremia.
Precautions
Generic name: Corace 5mg
Dosage form: tablet
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Hypertension
Initial therapy in adults: The recommended initial dose is 10 mg once a day. Adjust dosage according to blood pressure response. The usual dosage range is 20 to 40 mg per day administered in a single daily dose. Doses up to 80 mg have been used but do not appear to give a greater effect.
Use with Diuretics in Adults
If blood pressure is not controlled with Corace alone, a low dose of a diuretic may be added (e.g., hydrochlorothiazide 12.5 mg).
The recommended starting dose in adult patients with hypertension taking diuretics is 5 mg once per day.
Pediatric Patients 6 Years of Age and Older with Hypertension
For pediatric patients with glomerular filtration rate >30 mL/min/1.73 m2, the recommended starting dose is 0.07 mg/kg once daily (up to 5 mg total). Dosage should be adjusted according to blood pressure response up to a maximum of 0.61 mg/kg (up to 40 mg) once daily. Doses above 0.61 mg/kg (or in excess of 40 mg) have not been studied in pediatric patients.
Corace is not recommended in pediatric patients <6 years or in pediatric patients with glomerular filtration rate <30 mL/min/1.73 m2.
Heart Failure
The recommended starting dose for Corace, when used with diuretics and (usually) digitalis as adjunctive therapy is 5 mg once daily. The recommended starting dose in these patients with hyponatremia (serum sodium <130 mEq/L) is 2.5 mg once daily. Increase as tolerated to a maximum of 40 mg once daily.
Diuretic dose may need to be adjusted to help minimize hypovolemia, which may contribute to hypotension. The appearance of hypotension after the initial dose of Corace does not preclude subsequent careful dose titration with the drug, following effective management of the hypotension.
Acute Myocardial Infarction
In hemodynamically stable patients within 24 hours of the onset of symptoms of acute myocardial infarction, give Corace 5 mg orally, followed by 5 mg after 24 hours, 10 mg after 48 hours and then 10 mg once daily. Dosing should continue for at least 6 weeks.
Initiate therapy with 2.5 mg in patients with a low systolic blood pressure (100-120 mmHg) during the first 3 days after the infarct. If hypotension occurs (systolic blood pressure ≤100 mmHg) consider doses of 2.5 or 5 mg. If prolonged hypotension occurs (systolic blood pressure <90 mmHg for more than 1 hour) discontinue Corace.
Dose in Patients with Renal Impairment
No dose adjustment of Corace is required in patients with creatinine clearance >30 mL/min. In patients with creatinine clearance 10-30 mL/min, reduce the initial dose of Corace to half of the usual recommended dose (i.e., hypertension, 5 mg; heart failure or acute MI, 2.5 mg). For patients on hemodialysis or creatinine clearance <10 mL/min, the recommended initial dose is 2.5 mg once daily.
FAQs
